Hypokalaemic myopathy and myoglobinuria due to carbenoxolone sodium.

Muscle paresis and hypokalemia after treatment with duogastrone.

Carbenoxolone sodium (Biogastrone) has been used for several years in the treatment of gastric ulcer. The drug was considered unsuitable for the treatment of duodenal ulceration, as it is rapidly absorbed from the stomach and is thought to produce healing by a direct action on the mucosa. Recently, however, a capsule has been developed which is claimed to release the carbenoxolone at the pyloru...

Hypokalaemic paralysis due to carbenoxolone.

A 48 year old man was admitted with a four-day history of muscle cramps and paralysis. Two months previously the patient had been treated in another hospital for haematemesis arising from a lesser-curve gastric ulcer. At that time the serum potassium was 3.44 m.Eq/ 1. He received 6 units of whole blood. Five days later carbenoxolone sodium 150 mg daily was commenced. No other drugs were prescri...

Anorexia nervosa, liquorice and hypokalaemic myopathy.

A patient with a past history of anorexia nervosa developed a hypokalaemic myopathy following a 'flu-like illness. Although she was apparently in remission from anorexia nervosa, the diet was found to be markedly abnormal with an excessive ingestion of liquorice and a low potassium salt intake. The clinical features and investigations, including muscle biopsy, are described. The patient is comp...

Hereditary Metabolic Myopathy with Paroxysmal Myoglobinuria Due to Abnormal Glycolysis.

Duogastrone-induced hypokalaemic nephropathy and myopathy with myoglobinuria.

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